AirHint found the following cheapest return flights from Detroit (DTW) to Rome (FCO) in October 2025 (see full year).

Return flights

22 Oct - 05 Nov	Spirit Airlines
26 Oct - 03 Nov	Spirit Airlines
11 Oct - 23 Oct	Spirit Airlines
08 Oct - 15 Oct	Spirit Airlines
08 Oct - 21 Oct	Spirit Airlines
05 Oct - 21 Oct	Spirit Airlines
24 Oct - 01 Nov	Spirit Airlines
03 Oct - 25 Oct	Spirit Airlines
30 Oct - 06 Nov	Icelandair
27 Oct - 03 Nov	Icelandair
15 Oct - 22 Oct	United
21 Oct - 28 Oct	United
24 Oct - 31 Oct	United
18 Oct - 25 Oct	United
09 Oct - 16 Oct	Delta	direct

Also check the deals for one-way flights from Detroit to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Rome in October from 384€

Return flights