AirHint found the following cheapest return flights from Des Moines (DSM) to Rome (FCO) in December 2025 (see full year).
Return flights
| 27 Dec - 17 Jan | KLM | ||
| 15 Dec - 10 Jan | Allegiant Air | ||
| 28 Dec - 17 Jan | Air France | ||
| 26 Dec - 17 Jan | Allegiant Air |
Also check the deals for one-way flights from Des Moines to Rome in December.
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