AirHint found the following cheapest return flights from Denver (DEN) to Istanbul (IST) in September 2025 (see full year).

Return flights

27 Sep - 05 Oct	Frontier Airlines
27 Sep - 10 Oct	Frontier Airlines
27 Sep - 18 Oct	Frontier Airlines
22 Sep - 18 Oct	Frontier Airlines
20 Sep - 17 Oct	Frontier Airlines
27 Sep - 10 Oct	Turkish Airlines	direct
27 Sep - 18 Oct	Turkish Airlines	direct
20 Sep - 17 Oct	Turkish Airlines	direct
18 Sep - 23 Sep	Delta

Also check the deals for one-way flights from Denver to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Denver to Istanbul in September from 670€

Return flights