AirHint found the following cheapest return flights from Cancun (CUN) to Santiago (SCL) in October 2025 (see full year).

Return flights

02 Oct - 07 Oct	Sky Airline
07 Oct - 11 Oct	Sky Airline
09 Oct - 16 Oct	Sky Airline
25 Oct - 01 Nov	Sky Airline
02 Oct - 10 Oct	Arajet
31 Oct - 08 Nov	Avianca
26 Oct - 31 Oct	Arajet
05 Oct - 12 Oct	Copa
02 Oct - 09 Oct	Sky Airline
03 Oct - 07 Oct	Copa
31 Oct - 09 Nov	Avianca
04 Oct - 11 Oct	Sky Airline
03 Oct - 10 Oct	Copa
26 Oct - 02 Nov	Arajet
29 Oct - 03 Nov	Avianca

Also check the deals for one-way flights from Cancun to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cancun to Santiago in October from 334€

Return flights