AirHint found the following cheapest return flights from Cartagena (CTG) to Madrid (MAD) in September 2025 (see full year).

Return flights

18 Sep - 02 Oct	JetSmart
18 Sep - 25 Sep	JetSmart
17 Sep - 30 Sep	KLM
15 Sep - 30 Sep	KLM
13 Sep - 16 Oct	jetBlue
18 Sep - 28 Oct	KLM
18 Sep - 29 Sep	KLM
19 Sep - 25 Sep	KLM
15 Sep - 29 Oct	KLM
15 Sep - 27 Sep	Plus Ultra Lineas Aereas
15 Sep - 04 Oct	Plus Ultra Lineas Aereas
17 Sep - 04 Oct	KLM
07 Sep - 26 Oct	KLM
14 Sep - 26 Oct	KLM
17 Sep - 06 Oct	KLM
15 Sep - 06 Oct	KLM
17 Sep - 28 Sep	KLM
06 Sep - 09 Sep	Avianca
01 Sep - 08 Sep	KLM
01 Sep - 17 Sep	KLM

Also check the deals for one-way flights from Cartagena to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cartagena to Madrid in September from 803€

Return flights