AirHint found the following cheapest return flights from Cartagena (CTG) to Madrid (MAD) in December 2025 (see full year).

Return flights

03 Dec - 31 Jan	SWISS
25 Dec - 25 Jan	KLM
24 Dec - 18 Jan	KLM
01 Dec - 30 Jan	KLM
03 Dec - 10 Dec	Spirit Airlines
15 Dec - 19 Jan	Plus Ultra Lineas Aereas
17 Dec - 18 Jan	KLM
22 Dec - 17 Jan	KLM
01 Dec - 29 Dec	Copa
22 Dec - 19 Jan	Plus Ultra Lineas Aereas
13 Dec - 30 Dec	KLM
14 Dec - 23 Dec	SWISS
17 Dec - 16 Jan	KLM
10 Dec - 17 Dec	Plus Ultra Lineas Aereas
01 Dec - 08 Dec	Plus Ultra Lineas Aereas
19 Dec - 10 Jan	Wingo
17 Dec - 24 Dec	SWISS
10 Dec - 20 Dec	SWISS
08 Dec - 22 Dec	Wingo
15 Dec - 23 Dec	KLM

Also check the deals for one-way flights from Cartagena to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cartagena to Madrid in December from 619€

Return flights