AirHint found the following cheapest return flights from Cartagena (CTG) to Madrid (MAD) in December 2025 (see full year).

Return flights

14 Dec - 26 Jan	Avianca
12 Dec - 24 Jan	Avianca
10 Dec - 19 Jan	Avianca
05 Dec - 02 Jan	Avianca
12 Dec - 02 Jan	Avianca
22 Dec - 19 Jan	Avianca
17 Dec - 18 Jan	Avianca
06 Dec - 17 Dec	Plus Ultra Lineas Aereas
08 Dec - 30 Dec	KLM
22 Dec - 17 Jan	Avianca
06 Dec - 24 Dec	Plus Ultra Lineas Aereas
20 Dec - 30 Dec	KLM
23 Dec - 09 Jan	Avianca
19 Dec - 03 Jan	Avianca
11 Dec - 13 Dec	Avianca

Also check the deals for one-way flights from Cartagena to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cartagena to Madrid in December from 658€

Return flights