AirHint found the following cheapest return flights from Columbus (CMH) to Rome (FCO) in September 2025 (see full year).

Return flights

08 Sep - 15 Sep	Spirit Airlines
12 Sep - 22 Sep	Spirit Airlines
09 Sep - 16 Sep	United
03 Sep - 10 Sep	United
17 Sep - 24 Sep	United
30 Sep - 07 Oct	United
24 Sep - 01 Oct	United
07 Sep - 14 Sep	United
11 Sep - 18 Sep	United
15 Sep - 22 Sep	United
01 Sep - 08 Sep	United
13 Sep - 20 Sep	United
27 Sep - 04 Oct	United
22 Sep - 01 Oct	Delta
25 Sep - 09 Oct	Allegiant Air

Also check the deals for one-way flights from Columbus to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Columbus to Rome in September from 472€

Return flights