AirHint found the following cheapest return flights from Charlotte (CLT) to Rome (FCO) in September 2025 (see full year).

Return flights

29 Sep - 14 Oct	United
26 Sep - 18 Oct	Spirit Airlines
26 Sep - 09 Oct	Spirit Airlines
25 Sep - 18 Oct	Frontier Airlines
26 Sep - 04 Oct	United
24 Sep - 01 Oct	Spirit Airlines
26 Sep - 09 Oct	Finnair	direct
23 Sep - 30 Sep	Spirit Airlines
20 Sep - 11 Oct	Frontier Airlines
29 Sep - 14 Oct	Finnair	direct
23 Sep - 30 Sep	Finnair	direct
24 Sep - 01 Oct	British Airways	direct

Also check the deals for one-way flights from Charlotte to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charlotte to Rome in September from 488€

Return flights