AirHint found the following cheapest return flights from Charlotte (CLT) to Rome (FCO) in September 2025 (see full year).

Return flights

23 Sep - 07 Oct	Spirit Airlines
05 Sep - 17 Sep	Spirit Airlines
26 Sep - 04 Oct	Spirit Airlines
19 Sep - 30 Sep	Spirit Airlines
01 Sep - 12 Sep	Spirit Airlines
01 Sep - 10 Sep	Spirit Airlines
01 Sep - 08 Sep	Spirit Airlines
01 Sep - 06 Sep	Spirit Airlines
01 Sep - 10 Sep	British Airways	direct
01 Sep - 12 Sep	British Airways	direct
02 Sep - 09 Sep	United
09 Sep - 16 Sep	United
24 Sep - 01 Oct	United
30 Sep - 07 Oct	United
27 Sep - 04 Oct	United

Also check the deals for one-way flights from Charlotte to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charlotte to Rome in September from 354€

Return flights