AirHint found the following cheapest return flights from Charlotte (CLT) to Rome (FCO) in September 2025 (see full year).

Return flights

05 Sep - 16 Sep	Frontier Airlines
15 Sep - 19 Sep	Spirit Airlines
08 Sep - 24 Sep	Spirit Airlines
15 Sep - 22 Sep	Spirit Airlines
05 Sep - 12 Sep	Frontier Airlines
26 Sep - 04 Oct	Spirit Airlines
11 Sep - 20 Sep	Spirit Airlines
01 Sep - 17 Sep	Spirit Airlines
21 Sep - 11 Oct	Spirit Airlines
13 Sep - 04 Oct	Spirit Airlines
14 Sep - 04 Oct	Spirit Airlines
14 Sep - 20 Sep	Spirit Airlines
01 Sep - 10 Sep	Spirit Airlines
08 Sep - 24 Sep	Finnair	direct
30 Sep - 07 Oct	United
28 Sep - 05 Oct	United
29 Sep - 06 Oct	United
24 Sep - 01 Oct	United
25 Sep - 02 Oct	United

Also check the deals for one-way flights from Charlotte to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charlotte to Rome in September from 458€

Return flights