AirHint found the following cheapest return flights from Charlotte (CLT) to Rome (FCO) in October 2025 (see full year).

Return flights

20 Oct - 15 Nov	Lufthansa
22 Oct - 15 Nov	Lufthansa
18 Oct - 08 Nov	Air Canada
16 Oct - 08 Nov	Spirit Airlines
22 Oct - 29 Oct	Lufthansa
15 Oct - 22 Oct	United
17 Oct - 08 Nov	Spirit Airlines
19 Oct - 25 Oct	Lufthansa
02 Oct - 16 Oct	United
02 Oct - 15 Oct	United
04 Oct - 15 Oct	United
03 Oct - 15 Oct	Delta
18 Oct - 25 Oct	Lufthansa
09 Oct - 01 Nov	Spirit Airlines
03 Oct - 13 Oct	Spirit Airlines
10 Oct - 01 Nov	Spirit Airlines
14 Oct - 28 Oct	Air Canada

Also check the deals for one-way flights from Charlotte to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charlotte to Rome in October from 434€

Return flights