AirHint found the following cheapest return flights from Charlotte (CLT) to Rome (FCO) in October 2025 (see full year).

Return flights

30 Oct - 06 Nov	Spirit Airlines
07 Oct - 16 Oct	Spirit Airlines
23 Oct - 03 Nov	Spirit Airlines
19 Oct - 25 Oct	Spirit Airlines
03 Oct - 14 Oct	Spirit Airlines
01 Oct - 06 Oct	Spirit Airlines
03 Oct - 13 Oct	Spirit Airlines
29 Oct - 05 Nov	United
14 Oct - 21 Oct	United
24 Oct - 31 Oct	United
19 Oct - 26 Oct	United
06 Oct - 13 Oct	United
09 Oct - 16 Oct	United

Also check the deals for one-way flights from Charlotte to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charlotte to Rome in October from 383€

Return flights