AirHint found the following cheapest return flights from Cali (CLO) to Guayaquil (GYE) in December 2025 (see full year).
Return flights
| 04 Dec - 08 Dec | Avianca | ||
| 26 Dec - 30 Dec | Avianca | ||
| 22 Dec - 01 Jan | Copa |
Also check the deals for one-way flights from Cali to Guayaquil in December.
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