AirHint found the following cheapest return flights from Rome (CIA) to Panama City (PTY) in December 2025 (see full year).

Return flights

06 Dec - 11 Dec	Ryanair
04 Dec - 14 Dec	Ryanair
07 Dec - 20 Dec	Ryanair
21 Dec - 31 Dec	Ryanair
23 Dec - 31 Dec	Ryanair
24 Dec - 31 Dec	Ryanair
21 Dec - 29 Dec	Ryanair
27 Dec - 10 Jan	Ryanair
30 Dec - 08 Jan	Ryanair
15 Dec - 11 Jan	Ryanair
30 Dec - 10 Jan	Ryanair
26 Dec - 10 Jan	Ryanair
15 Dec - 07 Jan	Ryanair
21 Dec - 02 Jan	Ryanair
27 Dec - 05 Jan	Ryanair
22 Dec - 04 Jan	Ryanair
20 Dec - 05 Jan	Ryanair
19 Dec - 29 Dec	Ryanair
26 Dec - 29 Dec	Ryanair

Also check the deals for one-way flights from Rome to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Panama City

Cheap car rent in Panama City

Cheapest return flights from Rome to Panama City in December from 1152€

Return flights