AirHint found the following cheapest return flights from Rome (CIA) to Istanbul (IST) in May 2026 (see full year).

Return flights

23 May - 31 May	Ryanair
09 May - 13 May	Ryanair
12 May - 20 May	Ryanair
12 May - 19 May	Ryanair
05 May - 08 May	Ryanair
02 May - 05 May	Ryanair
26 May - 05 Jun	Ryanair
14 May - 19 May	Ryanair
05 May - 12 May	Ryanair
09 May - 12 May	Ryanair
02 May - 08 May	Ryanair
21 May - 07 Jun	Ryanair
28 May - 04 Jun	Ryanair
29 May - 03 Jun	Ryanair
28 May - 03 Jun	Ryanair
29 May - 02 Jun	Ryanair
28 May - 02 Jun	Ryanair
29 May - 01 Jun	Ryanair
28 May - 01 Jun	Ryanair
27 May - 01 Jun	Ryanair

Also check the deals for one-way flights from Rome to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul

Cheapest return flights from Rome to Istanbul in May from 109€

Return flights