AirHint found the following cheapest return flights from Rome (CIA) to Istanbul (IST) in May 2026 (see full year).

Return flights

01 May - 08 May	Ryanair
17 May - 22 May	Ryanair
16 May - 21 May	Ryanair
04 May - 08 May	Ryanair
18 May - 21 May	Ryanair
16 May - 23 May	Ryanair
20 May - 22 May	Ryanair
30 May - 01 Jun	Ryanair
18 May - 22 May	Ryanair
27 May - 30 May	Ryanair
19 May - 22 May	Ryanair
30 May - 04 Jun	Ryanair
30 May - 03 Jun	Ryanair

Also check the deals for one-way flights from Rome to Istanbul in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Istanbul in May from 228€

Return flights