AirHint found the following cheapest return flights from Charleston (CHS) to Rome (FCO) in October 2025 (see full year).

Return flights

27 Oct - 03 Nov	Spirit Airlines
27 Oct - 02 Nov	Spirit Airlines
27 Oct - 04 Nov	Spirit Airlines
27 Oct - 05 Nov	Spirit Airlines
23 Oct - 29 Oct	Spirit Airlines
28 Oct - 02 Nov	Spirit Airlines
28 Oct - 05 Nov	Spirit Airlines
29 Oct - 05 Nov	Spirit Airlines
15 Oct - 28 Oct	Spirit Airlines
28 Oct - 01 Nov	Spirit Airlines
10 Oct - 18 Oct	United

Also check the deals for one-way flights from Charleston to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Charleston to Rome in October from 406€

Return flights