AirHint found the following cheapest return flights from Buffalo (BUF) to Panama City (PTY) in December 2025 (see full year).
Return flights
| 01 Dec - 08 Dec | United | ||
| 19 Dec - 25 Dec | Frontier Airlines | ||
| 30 Dec - 06 Jan | Frontier Airlines |
Also check the deals for one-way flights from Buffalo to Panama City in December.
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