AirHint found the following cheapest return flights from Brussels (BRU) to Santiago (SCL) in September 2025 (see full year).

Return flights

14 Sep - 22 Sep	Delta
26 Sep - 15 Oct	Delta
26 Sep - 17 Oct	Delta
11 Sep - 19 Oct	Iberia
12 Sep - 19 Oct	Iberia
08 Sep - 24 Sep	Iberia
11 Sep - 25 Sep	Iberia
10 Sep - 19 Oct	KLM
06 Sep - 28 Sep	Iberia
10 Sep - 12 Oct	Iberia
15 Sep - 21 Oct	Iberia For Level
12 Sep - 21 Sep	Iberia
08 Sep - 11 Sep	Iberia For Level
05 Sep - 14 Sep	Iberia
07 Sep - 27 Sep	Vueling Airlines
15 Sep - 21 Sep	British Airways

Also check the deals for one-way flights from Brussels to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Brussels to Santiago in September from 714€

Return flights