AirHint found the following cheapest return flights from Asuncion (ASU) to Santiago (SCL) in December 2025 (see full year).

Return flights

02 Dec - 05 Dec	JetSmart
02 Dec - 04 Dec	JetSmart
19 Dec - 07 Jan	JetSmart
19 Dec - 28 Dec	JetSmart
19 Dec - 02 Jan	JetSmart
26 Dec - 07 Jan	JetSmart
26 Dec - 28 Dec	JetSmart
26 Dec - 02 Jan	JetSmart
26 Dec - 02 Jan	LATAM Airlines Group	direct
19 Dec - 06 Jan	JetSmart
26 Dec - 06 Jan	JetSmart
22 Dec - 02 Jan	Copa

Also check the deals for one-way flights from Asuncion to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Asuncion to Santiago in December from 221€

Return flights