AirHint found the following cheapest one-way flights from Southampton (SOU) to Prague (PRG) in May 2026 (see full year).
One-Way flights
| 07 May | Aer Lingus | ||
| 26 May | Aer Lingus | ||
| 03 May | Aer Lingus | ||
| 24 May | Aer Lingus | ||
| 10 May | easyJet |
Also check the deals for return flights from Southampton to Prague in May.
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