AirHint found the following cheapest one-way flights from Southampton (SOU) to Prague (PRG) in December 2025 (see full year).
One-Way flights
| 19 Dec | easyJet | ||
| 21 Dec | Loganair | ||
| 20 Dec | easyJet | ||
| 07 Dec | KLM | ||
| 18 Dec | KLM |
Also check the deals for return flights from Southampton to Prague in December.
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