Cheapest one-way flights from San Francisco to Santiago in December from 211€

AirHint found the following cheapest one-way flights from San Francisco (SFO) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

07 Dec United
04 Dec United
31 Dec Frontier Airlines
30 Dec LATAM Airlines Group
28 Dec LATAM Airlines Group
13 Dec Frontier Airlines
03 Dec Copa
02 Dec Frontier Airlines
26 Dec Delta
11 Dec LATAM Airlines Group

Also check the deals for return flights from San Francisco to Santiago in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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