AirHint found the following cheapest one-way flights from Santiago (SCL) to Madrid (MAD) in April 2026 (see full year).

One-Way flights

12 Apr	LATAM Airlines Group
14 Apr	LATAM Airlines Group
13 Apr	LATAM Airlines Group
20 Apr	LATAM Airlines Group
16 Apr	LATAM Airlines Group
27 Apr	LATAM Airlines Group
09 Apr	LATAM Airlines Group
08 Apr	LATAM Airlines Group
15 Apr	LATAM Airlines Group
10 Apr	LATAM Airlines Group

Also check the deals for return flights from Santiago to Madrid in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santiago to Madrid in April from 446€

One-Way flights