Cheapest one-way flights from Santiago to Madrid in December from 384€

AirHint found the following cheapest one-way flights from Santiago (SCL) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

03 Dec LATAM Airlines Group
01 Dec LATAM Airlines Group
02 Dec LATAM Airlines Group
07 Dec Iberia direct
12 Dec Iberia direct
08 Dec LATAM Airlines Group direct
11 Dec Iberia direct
04 Dec Iberia direct
13 Dec Sky Airline
14 Dec Sky Airline

Also check the deals for return flights from Santiago to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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