Cheapest one-way flights from Santiago to Madrid in December from 425€

AirHint found the following cheapest one-way flights from Santiago (SCL) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

06 Dec Sky Airline
04 Dec Avianca
02 Dec Avianca
01 Dec Avianca
03 Dec Avianca
15 Dec LATAM Airlines Group
24 Dec Sky Airline
20 Dec Sky Airline
21 Dec LATAM Airlines Group
14 Dec LATAM Airlines Group

Also check the deals for return flights from Santiago to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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