AirHint found the following cheapest one-way flights from Santiago (SCL) to La Serena (LSC) in December 2025 (see full year).
One-Way flights
| 02 Dec | LATAM Airlines Group | direct | |
| 09 Dec | Sky Airline | direct | |
| 23 Dec | Sky Airline | direct | |
| 11 Dec | JetSmart | direct | |
| 22 Dec | Sky Airline | direct | |
| 24 Dec | LATAM Airlines Group | direct |
Also check the deals for return flights from Santiago to La Serena in December.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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