AirHint found the following cheapest one-way flights from Istanbul (SAW) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

12 Dec	Pegasus Airlines	direct
17 Dec	Pegasus Airlines	direct
10 Dec	Pegasus Airlines	direct
16 Dec	Pegasus Airlines	direct
02 Dec	Pegasus Airlines	direct
09 Dec	Pegasus Airlines	direct
13 Dec	Pegasus Airlines	direct
04 Dec	Pegasus Airlines	direct
11 Dec	Pegasus Airlines	direct
28 Dec	AJet

Also check the deals for return flights from Istanbul to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Istanbul to Madrid in December from 62€

One-Way flights