Cheapest one-way flights from Prague to Santiago in October from 591€

Best time to book flights for Prague (PRG) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest one-way flights from Prague (PRG) to Santiago (SCL) in October 2025 (see full year).

One-Way flights

02 Oct Vueling Airlines
05 Oct Vueling Airlines
01 Oct Iberia

Also check the deals for return flights from Prague to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago