AirHint found the following cheapest one-way flights from Chicago (MDW) to Panama City (PTY) in December 2025 (see full year).
One-Way flights
| 31 Dec | Frontier Airlines | ||
| 30 Dec | Frontier Airlines | ||
| 16 Dec | Frontier Airlines | ||
| 22 Dec | Frontier Airlines | ||
| 26 Dec | Frontier Airlines |
Also check the deals for return flights from Chicago to Panama City in December.
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