Cheapest one-way flights from Madrid to Santa Cruz in May from 349€

Best time to book flights for Madrid (MAD) to Santa Cruz (VVI) flights at AirHint

AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in May 2025 (see full year).

One-Way flights

14 May Air Europa direct
12 May Air Europa direct
21 May Air Europa direct
11 May Air Europa direct
18 May Air Europa direct
20 May LATAM Airlines Group
06 May LATAM Airlines Group
26 May Air Europa direct
08 May LATAM Airlines Group
10 May LATAM Airlines Group

Also check the deals for return flights from Madrid to Santa Cruz in May.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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