AirHint found the following cheapest one-way flights from Madrid (MAD) to Santa Cruz (VVI) in May 2026 (see full year).

One-Way flights

08 May	Avianca
12 May	Avianca
13 May	Avianca
30 May	Avianca
01 May	Boliviana de Aviacion	direct
11 May	Air Europa	direct
30 May	Air Europa	direct
13 May	Air Europa	direct
08 May	Boliviana de Aviacion	direct
03 May	Boliviana de Aviacion	direct

Also check the deals for return flights from Madrid to Santa Cruz in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Santa Cruz in May from 258€

One-Way flights