AirHint found the following cheapest one-way flights from Madrid (MAD) to Prague (PRG) in December 2025 (see full year).

One-Way flights

12 Dec	Wizz Air Malta
14 Dec	Ryanair	direct
16 Dec	Ryanair	direct
13 Dec	Ryanair	direct
17 Dec	Wizz Air Malta
10 Dec	Wizz Air Malta
02 Dec	Iberia
11 Dec	Wizz Air Malta
02 Dec	Ryanair	direct
31 Dec	Ryanair	direct

Also check the deals for return flights from Madrid to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Madrid to Prague in December from 51€

One-Way flights