Cheapest one-way flights from Madrid to Istanbul in April from 66€

AirHint found the following cheapest one-way flights from Madrid (MAD) to Istanbul (IST) in April 2026 (see full year).

One-Way flights

28 Apr Ryanair
24 Apr Ryanair
22 Apr Ryanair
21 Apr Wizz Air UK
09 Apr Wizz Air Malta
07 Apr Pegasus Airlines direct
06 Apr Pegasus Airlines direct
15 Apr Wizz Air UK
08 Apr Pegasus Airlines direct
25 Apr Wizz Air UK

Also check the deals for return flights from Madrid to Istanbul in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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