AirHint found the following cheapest one-way flights from Lyon (LYS) to Rome (FCO) in September 2025 (see full year).

One-Way flights

30 Sep	easyJet	direct
23 Sep	easyJet	direct
28 Sep	easyJet	direct
29 Sep	easyJet	direct
22 Sep	easyJet	direct
15 Sep	easyJet	direct
16 Sep	easyJet	direct
24 Sep	Vueling Airlines
25 Sep	Wizz Air Malta
18 Sep	easyJet	direct

Also check the deals for return flights from Lyon to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Lyon to Rome in September from 28€

One-Way flights