AirHint found the following cheapest one-way flights from Santorini (Thira) (JTR) to Prague (PRG) in September 2025 (see full year).

One-Way flights

26 Sep	Volotea
30 Sep	Aegean Airlines
23 Sep	Aegean Airlines
25 Sep	easyJet
28 Sep	Aegean Airlines
29 Sep	Aegean Airlines
26 Sep	Smart Wings	direct
23 Sep	Smart Wings	direct
24 Sep	Volotea
27 Sep	SKY express

Also check the deals for return flights from Santorini (Thira) to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santorini (Thira) to Prague in September from 155€

One-Way flights