AirHint found the following cheapest one-way flights from Houston (HOU) to Madrid (MAD) in October 2025 (see full year).
One-Way flights
| 24 Oct | Frontier Airlines | ||
| 22 Oct | Spirit Airlines | ||
| 20 Oct | Spirit Airlines | ||
| 19 Oct | Frontier Airlines | ||
| 27 Oct | United |
Also check the deals for return flights from Houston to Madrid in October.
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