AirHint found the following cheapest one-way flights from Detroit (DTW) to Istanbul (IST) in October 2025 (see full year).
One-Way flights
| 24 Oct | Spirit Airlines | ||
| 17 Oct | Spirit Airlines | ||
| 21 Oct | Turkish Airlines | direct | |
| 26 Oct | Turkish Airlines | direct | |
| 17 Oct | Turkish Airlines | direct | |
| 24 Oct | Turkish Airlines | direct |
Also check the deals for return flights from Detroit to Istanbul in October.
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