AirHint found the following cheapest return flights from Santiago (SCQ) to Brussels (BRU) in December 2025 (see full year).

Return flights

15 Dec - 04 Jan	Vueling Airlines
25 Dec - 04 Jan	Vueling Airlines
12 Dec - 15 Dec	Ryanair
29 Dec - 04 Jan	Vueling Airlines
02 Dec - 15 Dec	Vueling Airlines
06 Dec - 15 Dec	Vueling Airlines
15 Dec - 15 Dec	Vueling Airlines
15 Dec - 30 Dec	Vueling Airlines
12 Dec - 30 Dec	Vueling Airlines
25 Dec - 28 Dec	Vueling Airlines
15 Dec - 22 Dec	Vueling Airlines
02 Dec - 22 Dec	Vueling Airlines
06 Dec - 22 Dec	Vueling Airlines

Also check the deals for one-way flights from Santiago to Brussels in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Brussels in December from 121€

Return flights