AirHint found the following cheapest return flights from Santiago (SCL) to Quito (UIO) in October 2025 (see full year).

Return flights

01 Oct - 05 Oct	JetSmart
31 Oct - 07 Nov	JetSmart
01 Oct - 10 Oct	JetSmart
01 Oct - 12 Oct	JetSmart
10 Oct - 17 Oct	JetSmart
03 Oct - 05 Oct	JetSmart
22 Oct - 05 Nov	JetSmart
01 Oct - 08 Oct	JetSmart
01 Oct - 17 Oct	JetSmart
01 Oct - 15 Oct	JetSmart
22 Oct - 09 Nov	JetSmart
22 Oct - 07 Nov	JetSmart
20 Oct - 27 Oct	Avianca
18 Oct - 23 Oct	Avianca
24 Oct - 05 Nov	JetSmart
06 Oct - 03 Nov	Avianca
24 Oct - 09 Nov	JetSmart
24 Oct - 07 Nov	JetSmart
17 Oct - 05 Nov	JetSmart
26 Oct - 05 Nov	JetSmart

Also check the deals for one-way flights from Santiago to Quito in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Quito in October from 303€

Return flights