AirHint found the following cheapest return flights from San Diego (SAN) to Rome (FCO) in September 2025 (see full year).

Return flights

09 Sep - 16 Sep	United
03 Sep - 23 Sep	Air Canada
03 Sep - 12 Sep	Air Canada
16 Sep - 23 Sep	Air Canada
30 Sep - 07 Oct	United
03 Sep - 10 Sep	United
09 Sep - 18 Sep	Air France
17 Sep - 24 Sep	United
22 Sep - 13 Oct	Lufthansa
24 Sep - 01 Oct	Delta
15 Sep - 22 Sep	United
11 Sep - 18 Sep	United
25 Sep - 02 Oct	Delta
01 Sep - 08 Sep	Delta
22 Sep - 12 Oct	Delta
25 Sep - 03 Oct	British Airways
27 Sep - 04 Oct	United

Also check the deals for one-way flights from San Diego to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Diego to Rome in September from 469€

Return flights