AirHint found the following cheapest return flights from San Diego (SAN) to Rome (FCO) in September 2025 (see full year).

Return flights

09 Sep - 16 Sep	United
30 Sep - 07 Oct	United
22 Sep - 30 Sep	Air Canada
24 Sep - 10 Oct	United
24 Sep - 01 Oct	United
01 Sep - 12 Sep	British Airways
20 Sep - 16 Oct	Iberia
02 Sep - 09 Sep	Delta
03 Sep - 10 Sep	United
15 Sep - 22 Sep	United
21 Sep - 28 Sep	United
27 Sep - 02 Oct	Spirit Airlines
14 Sep - 27 Sep	United
01 Sep - 20 Sep	British Airways
18 Sep - 25 Sep	United
11 Sep - 06 Oct	Lufthansa
27 Sep - 04 Oct	United

Also check the deals for one-way flights from San Diego to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Diego to Rome in September from 468€

Return flights