AirHint found the following cheapest return flights from San Diego (SAN) to Rome (FCO) in October 2025 (see full year).

Return flights

14 Oct - 23 Oct	Air Canada
21 Oct - 05 Nov	United
29 Oct - 05 Nov	United
13 Oct - 22 Oct	United
15 Oct - 22 Oct	United
21 Oct - 28 Oct	United
24 Oct - 31 Oct	United
24 Oct - 09 Nov	United
16 Oct - 24 Oct	Lufthansa
16 Oct - 30 Oct	Lufthansa
17 Oct - 30 Oct	Lufthansa
06 Oct - 13 Oct	United
12 Oct - 19 Oct	United

Also check the deals for one-way flights from San Diego to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Diego to Rome in October from 424€

Return flights