AirHint found the following cheapest return flights from Raleigh-durham (RDU) to Panama City (PTY) in September 2025 (see full year).

Return flights

29 Sep - 08 Oct	Copa	direct
30 Sep - 07 Oct	United
29 Sep - 07 Oct	United
30 Sep - 08 Oct	United
30 Sep - 09 Oct	United
29 Sep - 06 Oct	Frontier Airlines
28 Sep - 07 Oct	Frontier Airlines
28 Sep - 05 Oct	Frontier Airlines
25 Sep - 02 Oct	Spirit Airlines
22 Sep - 29 Sep	Frontier Airlines
27 Sep - 05 Oct	Frontier Airlines
22 Sep - 30 Sep	Frontier Airlines
21 Sep - 28 Sep	Frontier Airlines
19 Sep - 28 Sep	Frontier Airlines
23 Sep - 30 Sep	Frontier Airlines
21 Sep - 29 Sep	Frontier Airlines
26 Sep - 29 Sep	Copa	direct
22 Sep - 29 Sep	Copa	direct
20 Sep - 28 Sep	Frontier Airlines
18 Sep - 26 Sep	Frontier Airlines

Also check the deals for one-way flights from Raleigh-durham to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Raleigh-durham to Panama City in September from 209€

Return flights