AirHint found the following cheapest return flights from Panama City (PTY) to Santiago (SCL) in September 2025 (see full year).

Return flights

17 Sep - 02 Oct	Wingo
28 Sep - 05 Oct	Wingo
22 Sep - 06 Oct	Avianca
01 Sep - 07 Sep	Avianca
01 Sep - 08 Sep	Avianca
16 Sep - 30 Sep	Avianca
01 Sep - 13 Sep	Avianca
22 Sep - 06 Oct	Copa	direct
16 Sep - 30 Sep	Copa	direct
17 Sep - 02 Oct	Copa	direct
01 Sep - 08 Sep	Copa	direct
01 Sep - 13 Sep	Copa	direct

Also check the deals for one-way flights from Panama City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santiago in September from 468€

Return flights