AirHint found the following cheapest return flights from Panama City (PTY) to Santiago (SCL) in October 2025 (see full year).

Return flights

29 Oct - 24 Nov	Avianca
22 Oct - 29 Oct	Avianca
23 Oct - 27 Oct	Avianca
19 Oct - 30 Oct	Avianca
30 Oct - 05 Nov	Avianca
30 Oct - 15 Nov	Avianca
31 Oct - 05 Nov	Avianca
31 Oct - 12 Nov	Avianca
30 Oct - 05 Nov	Copa	direct
29 Oct - 24 Nov	Copa	direct
31 Oct - 12 Nov	Copa	direct
31 Oct - 05 Nov	Copa	direct
22 Oct - 29 Oct	Copa	direct
23 Oct - 27 Oct	Copa	direct
19 Oct - 30 Oct	Copa	direct

Also check the deals for one-way flights from Panama City to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santiago in October from 456€

Return flights