AirHint found the following cheapest return flights from Panama City (PTY) to Santiago (SCL) in October 2025 (see full year).

Return flights

12 Oct - 17 Oct	Wingo
31 Oct - 02 Nov	Wingo
30 Oct - 08 Nov	Wingo
31 Oct - 15 Nov	Avianca
12 Oct - 14 Oct	Avianca
29 Oct - 05 Nov	Copa	direct
12 Oct - 17 Oct	Copa	direct
31 Oct - 02 Nov	Copa	direct
30 Oct - 08 Nov	Copa	direct
31 Oct - 15 Nov	Copa	direct
30 Oct - 15 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santiago in October from 491€

Return flights