AirHint found the following cheapest return flights from Panama City (PTY) to Guatemala City (GUA) in October 2025 (see full year).

Return flights

20 Oct - 27 Oct	Avianca
24 Oct - 29 Oct	Avianca
31 Oct - 03 Nov	Avianca
27 Oct - 03 Nov	Avianca
02 Oct - 09 Oct	Avianca
26 Oct - 04 Nov	Avianca
29 Oct - 02 Nov	Avianca
31 Oct - 05 Nov	Avianca
23 Oct - 27 Oct	Avianca
10 Oct - 13 Oct	Avianca
11 Oct - 12 Oct	Avianca
31 Oct - 09 Nov	Avianca
25 Oct - 06 Nov	Avianca
17 Oct - 21 Oct	Copa
10 Oct - 13 Oct	Copa	direct
23 Oct - 27 Oct	Copa	direct
26 Oct - 04 Nov	Copa	direct
29 Oct - 02 Nov	Copa	direct
20 Oct - 27 Oct	Copa	direct

Also check the deals for one-way flights from Panama City to Guatemala City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Guatemala City in October from 218€

Return flights