AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in September 2025 (see full year).

Return flights

29 Sep - 04 Oct	Ryanair
23 Sep - 30 Sep	Aeroitalia
27 Sep - 01 Oct	Ryanair
27 Sep - 04 Oct	Ryanair
13 Sep - 16 Sep	Ryanair
13 Sep - 20 Sep	Ryanair
16 Sep - 23 Sep	Aeroitalia
25 Sep - 27 Sep	Ryanair
18 Sep - 21 Sep	Aeroitalia
22 Sep - 26 Sep	Ryanair
26 Sep - 04 Oct	Volotea
16 Sep - 21 Sep	Aeroitalia
18 Sep - 25 Sep	Ryanair
20 Sep - 24 Sep	Ryanair
30 Sep - 03 Oct	Volotea
30 Sep - 12 Oct	Vueling Airlines
30 Sep - 13 Oct	Vueling Airlines
25 Sep - 12 Oct	Vueling Airlines
25 Sep - 13 Oct	Vueling Airlines
30 Sep - 20 Oct	Vueling Airlines

Also check the deals for one-way flights from Palermo to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in September from 130€

Return flights