AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in December 2025 (see full year).

Return flights

01 Dec - 06 Dec	Ryanair
27 Dec - 01 Jan	Ryanair
04 Dec - 06 Dec	Ryanair
08 Dec - 12 Dec	Ryanair
07 Dec - 12 Dec	Ryanair
01 Dec - 05 Dec	Ryanair
07 Dec - 11 Dec	easyJet
09 Dec - 12 Dec	Ryanair
02 Dec - 06 Dec	easyJet
08 Dec - 11 Dec	Ryanair
13 Dec - 15 Dec	Ryanair
26 Dec - 07 Jan	easyJet
27 Dec - 02 Jan	SWISS
31 Dec - 01 Jan	Ryanair
27 Dec - 03 Jan	Ryanair
26 Dec - 01 Jan	Ryanair
31 Dec - 04 Jan	Ryanair
31 Dec - 05 Jan	Ryanair
30 Dec - 01 Jan	Ryanair
31 Dec - 03 Jan	Ryanair

Also check the deals for one-way flights from Palermo to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in December from 130€

Return flights