AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in December 2025 (see full year).

Return flights

27 Dec - 01 Jan	Ryanair
27 Dec - 31 Dec	Ryanair
27 Dec - 04 Jan	Ryanair
24 Dec - 16 Jan	Vueling Airlines
27 Dec - 03 Jan	Ryanair
31 Dec - 01 Jan	Ryanair
31 Dec - 04 Jan	Ryanair
27 Dec - 02 Jan	Ryanair
29 Dec - 06 Jan	Ryanair
26 Dec - 03 Jan	Ryanair
31 Dec - 03 Jan	Ryanair
24 Dec - 31 Dec	Aeroitalia
26 Dec - 30 Dec	SWISS
25 Dec - 29 Dec	Vueling Airlines
29 Dec - 31 Dec	Volotea
27 Dec - 29 Dec	Ryanair
27 Dec - 30 Dec	Ryanair
26 Dec - 29 Dec	Ryanair
24 Dec - 27 Dec	Aeroitalia
24 Dec - 28 Dec	Aeroitalia

Also check the deals for one-way flights from Palermo to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in December from 168€

Return flights