AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in April 2026 (see full year).

Return flights

18 Apr - 25 Apr	Ryanair
23 Apr - 27 Apr	Ryanair
19 Apr - 25 Apr	Ryanair
20 Apr - 25 Apr	Ryanair
11 Apr - 15 Apr	Ryanair
16 Apr - 22 Apr	Ryanair
15 Apr - 23 Apr	Ryanair
14 Apr - 21 Apr	Eurowings
17 Apr - 24 Apr	Ryanair
30 Apr - 04 May	easyJet
21 Apr - 26 Apr	Ryanair
28 Apr - 06 May	easyJet
25 Apr - 02 May	Ryanair
29 Apr - 02 May	Air Serbia
30 Apr - 02 May	easyJet
24 Apr - 02 May	Ryanair
27 Apr - 02 May	Volotea
26 Apr - 02 May	Ryanair
27 Apr - 05 May	Ryanair
25 Apr - 03 May	Ryanair

Also check the deals for one-way flights from Palermo to Istanbul in April.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in April from 148€

Return flights