AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in December 2025 (see full year).

Return flights

10 Dec - 15 Dec	Ryanair
01 Dec - 04 Dec	Ryanair
03 Dec - 06 Dec	Ryanair
01 Dec - 07 Dec	Ryanair
03 Dec - 07 Dec	Aeroitalia
10 Dec - 14 Dec	Ryanair
08 Dec - 12 Dec	Ryanair
01 Dec - 31 Dec	Ryanair
12 Dec - 17 Dec	easyJet
05 Dec - 07 Dec	Ryanair
31 Dec - 07 Jan	Ryanair
28 Dec - 01 Jan	Ryanair
26 Dec - 01 Jan	Ryanair
27 Dec - 01 Jan	Ryanair
31 Dec - 06 Jan	Ryanair
20 Dec - 02 Jan	Ryanair
24 Dec - 02 Jan	Aeroitalia
25 Dec - 01 Jan	Transavia France
31 Dec - 05 Jan	Ryanair
29 Dec - 05 Jan	Ryanair

Also check the deals for one-way flights from Palermo to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul

Cheapest return flights from Palermo to Istanbul in December from 185€

Return flights