AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in December 2025 (see full year).

Return flights

10 Dec - 14 Dec	Ryanair
08 Dec - 12 Dec	Ryanair
03 Dec - 10 Dec	Aeroitalia
02 Dec - 07 Dec	Ryanair
08 Dec - 10 Dec	Ryanair
01 Dec - 14 Dec	Ryanair
08 Dec - 14 Dec	Ryanair
12 Dec - 14 Dec	Ryanair
01 Dec - 07 Dec	Ryanair
03 Dec - 07 Dec	Ryanair
19 Dec - 07 Jan	Aeroitalia
31 Dec - 09 Jan	Ryanair
19 Dec - 08 Jan	Ryanair
25 Dec - 01 Jan	ITA Airways
21 Dec - 01 Jan	Ryanair
27 Dec - 02 Jan	Volotea
31 Dec - 04 Jan	Ryanair
31 Dec - 07 Jan	Ryanair
31 Dec - 05 Jan	Ryanair
31 Dec - 09 Jan	Turkish Airlines	direct

Also check the deals for one-way flights from Palermo to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in December from 150€

Return flights