AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in November 2025 (see full year).

Return flights

24 Nov - 26 Nov	Ryanair
07 Nov - 16 Nov	Ryanair
21 Nov - 24 Nov	Ryanair
07 Nov - 17 Nov	Ryanair
17 Nov - 21 Nov	Ryanair
21 Nov - 24 Nov	Turkish Airlines	direct
20 Nov - 24 Nov	Vueling Airlines
07 Nov - 17 Nov	Turkish Airlines	direct
18 Nov - 23 Nov	ITA Airways
07 Nov - 12 Nov	Turkish Airlines	direct
30 Nov - 07 Dec	Turkish Airlines	direct

Also check the deals for one-way flights from Palermo to Istanbul in November.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in November from 173€

Return flights