AirHint found the following cheapest return flights from Palermo (PMO) to Istanbul (IST) in October 2025 (see full year).

Return flights

15 Oct - 18 Oct	Ryanair
01 Oct - 15 Oct	Ryanair
08 Oct - 15 Oct	Ryanair
17 Oct - 22 Oct	Volotea
14 Oct - 19 Oct	easyJet
09 Oct - 22 Oct	easyJet
01 Oct - 05 Oct	Ryanair
06 Oct - 12 Oct	Ryanair
01 Oct - 03 Oct	Ryanair
15 Oct - 20 Oct	Ryanair
26 Oct - 08 Nov	easyJet

Also check the deals for one-way flights from Palermo to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Istanbul in October from 151€

Return flights