AirHint found the following cheapest return flights from Chicago (ORD) to Rome (FCO) in October 2025 (see full year).

Return flights

23 Oct - 26 Oct	TAP
17 Oct - 26 Oct	TAP
08 Oct - 15 Oct	TAP
17 Oct - 28 Oct	TAP
29 Oct - 11 Nov	TAP
22 Oct - 28 Oct	TAP
05 Oct - 15 Oct	TAP
30 Oct - 06 Nov	Icelandair
28 Oct - 11 Nov	Lufthansa
22 Oct - 05 Nov	Lufthansa
10 Oct - 17 Oct	TAP
02 Oct - 15 Oct	TAP
03 Oct - 12 Oct	TAP
15 Oct - 25 Oct	TAP
30 Oct - 05 Nov	Icelandair
28 Oct - 02 Nov	Lufthansa
23 Oct - 06 Nov	Spirit Airlines
19 Oct - 02 Nov	Spirit Airlines
01 Oct - 08 Nov	Delta

Also check the deals for one-way flights from Chicago to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Rome in October from 322€

Return flights