AirHint found the following cheapest return flights from Chicago (ORD) to Rome (FCO) in October 2025 (see full year).

Return flights

30 Oct - 22 Nov	Icelandair
31 Oct - 22 Nov	Icelandair
22 Oct - 05 Nov	Lufthansa
29 Oct - 06 Nov	Lufthansa
21 Oct - 11 Nov	Lufthansa
20 Oct - 24 Nov	Lufthansa
29 Oct - 12 Nov	SWISS
29 Oct - 04 Nov	Lufthansa
28 Oct - 04 Nov	Lufthansa
26 Oct - 03 Nov	Air Canada
17 Oct - 24 Oct	Iberia
29 Oct - 31 Oct	Spirit Airlines
27 Oct - 31 Oct	Frontier Airlines
25 Oct - 30 Oct	Frontier Airlines
21 Oct - 23 Oct	Condor
20 Oct - 23 Oct	Frontier Airlines
24 Oct - 29 Oct	Frontier Airlines
24 Oct - 28 Oct	Frontier Airlines
21 Oct - 28 Oct	SWISS
23 Oct - 28 Oct	Frontier Airlines

Also check the deals for one-way flights from Chicago to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Rome in October from 349€

Return flights