AirHint found the following cheapest return flights from Mexico City (MEX) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

08 Sep - 19 Sep	Avianca
03 Sep - 08 Sep	Avianca
06 Sep - 13 Sep	Avianca
25 Sep - 30 Sep	Avianca
18 Sep - 26 Sep	Avianca
04 Sep - 07 Sep	Avianca
20 Sep - 27 Sep	Avianca
19 Sep - 26 Sep	Avianca
23 Sep - 27 Sep	Avianca
07 Sep - 13 Sep	Avianca
27 Sep - 04 Oct	Avianca
21 Sep - 02 Oct	Avianca
26 Sep - 03 Oct	Avianca
25 Sep - 01 Oct	Avianca
25 Sep - 02 Oct	Copa
22 Sep - 03 Oct	Copa
21 Sep - 02 Oct	LATAM Airlines Group	direct
28 Sep - 13 Oct	Arajet
26 Sep - 03 Oct	LATAM Airlines Group	direct
14 Sep - 01 Oct	Arajet

Also check the deals for one-way flights from Mexico City to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Mexico City to Sao Paulo in September from 384€

Return flights