AirHint found the following cheapest return flights from Chicago (MDW) to Istanbul (IST) in December 2025 (see full year).

Return flights

02 Dec - 08 Dec	Frontier Airlines
02 Dec - 09 Dec	Frontier Airlines
09 Dec - 16 Dec	Frontier Airlines
03 Dec - 27 Dec	KLM
16 Dec - 10 Jan	Frontier Airlines
01 Dec - 09 Dec	KLM
01 Dec - 10 Dec	KLM
28 Dec - 17 Jan	Frontier Airlines
02 Dec - 27 Dec	KLM
08 Dec - 29 Jan	Delta
13 Dec - 16 Dec	Frontier Airlines
10 Dec - 24 Dec	Delta
31 Dec - 09 Jan	Frontier Airlines
04 Dec - 08 Dec	Frontier Airlines
04 Dec - 29 Jan	Delta
27 Dec - 16 Jan	Frontier Airlines
04 Dec - 19 Jan	Delta
30 Dec - 10 Jan	Delta
29 Dec - 09 Jan	Frontier Airlines
30 Dec - 08 Jan	Frontier Airlines

Also check the deals for one-way flights from Chicago to Istanbul in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Chicago to Istanbul in December from 561€

Return flights