AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in September 2025 (see full year).

Return flights

30 Sep - 07 Oct	LATAM Airlines Group
28 Sep - 05 Oct	JetSmart
28 Sep - 01 Oct	JetSmart
29 Sep - 05 Oct	JetSmart
29 Sep - 20 Oct	JetSmart
27 Sep - 05 Oct	JetSmart
29 Sep - 01 Oct	JetSmart
27 Sep - 01 Oct	JetSmart
25 Sep - 29 Sep	Copa
17 Sep - 21 Sep	Copa
28 Sep - 17 Oct	JetSmart
28 Sep - 06 Oct	JetSmart
18 Sep - 20 Sep	Copa
28 Sep - 30 Sep	JetSmart
27 Sep - 30 Sep	JetSmart
25 Sep - 26 Sep	JetSmart
27 Sep - 29 Sep	JetSmart
28 Sep - 29 Sep	JetSmart
25 Sep - 30 Sep	JetSmart
17 Sep - 26 Sep	JetSmart

Also check the deals for one-way flights from Rio Negro to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Rio Negro to Santiago in September from 340€

Return flights